Research interests

1. Emerging and Zoonotic Diseases
2. Virome
3. Molecular mechanism of host-shift of avian influenza viruses and coronaviruses

 Employment

2010-2012 Associate researcher, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of           

                      Zoology, Chinese Academy of Sciences, Kunming, China

2013-2015 Researcher, Joint Influenza Research Centre, Shantou University Medical College, Shantou, China

2016-2024 Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

2025-Present Professor, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Education

2004 BSc, Biology, University of Science and Technology of China

2010 Ph.D., Genetics, University of Chinese Academy of Sciences

Publications (*co-first author)

1. Meng, Y., Irwin, D.M., and Shen, Y*., Ecology of SARS-CoV-2 in the post-pandemic era. Lancet Microbe, 2023. 4(4): p. e208.

2. Liang, X., Zhang, Z., Wang, H., Lu, X., Li, W., Lu, H., Roy, A., Shen, X., Irwin, D.M., and Shen, Y*., Early-life prophylactic antibiotic treatment disturbs the stability of the gut microbiota and increases susceptibility to H9N2 AIV in chicks. Microbiome, 2023. 11(1): p. 163.

3. Liang, X., Chen, X., Zhai, J., Li, X., Zhang, X., Zhang, Z., Zhang, P., Wang, X., Cui, X., Wang, H., Zhou, N., Chen, Z.J., Su, R., Zhou, F., Holmes, E.C., Irwin, D.M., Chen, R.A., He, Q., Wu, Y.J., Wang, C., Du, X.Q., Peng, S.M., Xie, W.J., Shan, F., Li, W.P., Dai, J.W., Shen, X., Feng, Y., Xiao, L., Chen, W*., and Shen, Y*., Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins. PLoS Pathog, 2023. 19(5): p. e1011384.

4. Huang, X.Y., Chen, Q., Sun, M.X., Zhou, H.Y., Ye, Q., Chen, W., Peng, J.Y., Qi, Y.N., Zhai, J.Q., Tian, Y., Liu, Z.X., Huang, Y.J., Deng, Y.Q., Li, X.F., Wu, A., Yang, X., Yang, G*., Shen, Y*., and Qin, C.F*., A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity. Cell Discov, 2023. 9(1): p. 59.

5. Cui, X., Fan, K., Liang, X., Gong, W., Chen, W., He, B., Chen, X., Wang, H., Wang, X., Zhang, P., Lu, X., Chen, R., Lin, K., Liu, J., Zhai, J., Liu, D.X., Shan, F., Li, Y., Chen, R.A., Meng, H., Li, X., Mi, S., Jiang, J., Zhou, N., Chen, Z., Zou, J.J., Ge, D., Yang, Q., He, K., Chen, T., Wu, Y.J., Lu, H., Irwin, D.M., Shen, X., Hu, Y., Lu, X., Ding, C*., Guan, Y*., Tu, C*., and Shen, Y*., Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals. Nat Commun, 2023. 14(1): p. 2488.

6. Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.J., Li, N., Guo, Y., Li, X., Shen, X., Zhang, Z., Shu, F., Huang, W., Li, Y., Zhang, Z., Chen, R.A., Wu, Y.J., Peng, S.M., Huang, M., Xie, W.J., Cai, Q.H., Hou, F.H., Chen, W*., Xiao, L*., and Shen, Y*., Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature, 2020. 583(7815): p. 286-289.

7. Zhang, X., Luo, T., and Shen, Y*., Deciphering the Sharp Decrease in H7N9 Human Infections. Trends Microbiol, 2018. 26(12): p. 971-973.

8. Xiang, D., Shen, X., Pu, Z., Irwin, D.M., Liao, M., and Shen, Y*., Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. J Infect Dis, 2018. 217(11): p. 1699-1707.

9. Sabir, J.S^#., Lam, T.T^#., Ahmed, M.M^#., Li, L^#., Shen, Y., Abo-Aba, S.E., Qureshi, M.I., Abu-Zeid, M., Zhang, Y., Khiyami, M.A., Alharbi, N.S., Hajrah, N.H., Sabir, M.J., Mutwakil, M.H., Kabli, S.A., Alsulaimany, F.A., Obaid, A.Y., Zhou, B., Smith, D.K., Holmes, E.C., Zhu, H., and Guan, Y., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. Science, 2016. 351(6268): p. 81-4.

10. Lam, T.T^#., Zhou, B^#., Wang, J^#., Chai, Y^#., Shen, Y^#., Chen, X^#., Ma, C., Hong, W., Chen, Y., Zhang, Y., Duan, L., Chen, P., Jiang, J., Zhang, Y., Li, L., Poon, L.L., Webby, R.J., Smith, D.K., Leung, G.M., Peiris, J.S., Holmes, E.C., Guan, Y., and Zhu, H., Dissemination, divergence and establishment of H7N9 influenza viruses in China. Nature, 2015. 522(7554): p. 102-5.

11. Lam, T.T^#., Wang, J^#., Shen, Y^#., Zhou, B., Duan, L., Cheung, C.L., Ma, C., Lycett, S.J., Leung, C.Y., Chen, X., Li, L., Hong, W., Chai, Y., Zhou, L., Liang, H., Ou, Z., Liu, Y., Farooqui, A., Kelvin, D.J., Poon, L.L., Smith, D.K., Pybus, O.G., Leung, G.M., Shu, Y., Webster, R.G., Webby, R.J., Peiris, J.S., Rambaut, A., Zhu, H., and Guan, Y., The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature, 2013. 502(7470): p. 241-4.